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Gyro Meat Loaf with Tzatziki Sauce

A spin on a classic meat loaf, I love this because I can sneak spinach in on my meat-and-potatoes family. Serve it with Greek-style potatoes or a Greek salad. I also get to make a whole other meal the next night with the leftovers—gyros. —Mandy Rivers, Lexington, South Carolina
  • Total Time
    Prep: 20 min. Bake: 55 min. + standing
  • Makes
    8 servings


  • 1 package (10 ounces) frozen chopped spinach, thawed and squeezed dry
  • 1 cup dry bread crumbs
  • 1 small onion, finely chopped
  • 2 large eggs, lightly beaten
  • 1/4 cup grated Romano cheese
  • 2 teaspoons dried oregano
  • 1-1/2 teaspoons garlic powder
  • 1/2 teaspoon salt
  • 2 pounds ground lamb or beef
  • 1 cup refrigerated tzatziki sauce


  • Preheat oven to 350°. In a large bowl, combine the first eight ingredients. Crumble lamb over mixture and mix well. Shape into a loaf and place in a greased 11x7-in. baking dish.
  • Bake, uncovered, 55-60 minutes or until no pink remains and a thermometer reads 160°. Let stand 15 minutes before slicing. Serve with tzatziki sauce.
    Freeze option: Securely wrap and freeze cooled meat loaf in plastic wrap and foil. To use, partially thaw in refrigerator overnight. Unwrap meat loaf; reheat on a greased shallow baking pan in a preheated 350° oven until a thermometer inserted in center reads 165°.
Nutrition Facts
1 slice with 2 tablespoons sauce: 354 calories, 21g fat (9g saturated fat), 136mg cholesterol, 472mg sodium, 15g carbohydrate (2g sugars, 2g fiber), 26g protein.

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  • Kgarret8
    Oct 21, 2014

    I will preface this by saying I do not like meat loaf. This one though is absolutely delicious! I made this tonight and it was a hit. I did half lamb and half beef. Everything else was by the recipe. I used Alton Browns Tzatziki sauce recipe since I couldn't find refrigerated version.

  • angelasandoval
    Mar 27, 2013

    No comment left

  • KelliT
    Mar 14, 2013

    This is delicious & satisfies the craving for gyros. I've made it twice in the past 2 weeks. I used ground turkey in place of the lamb. I like that there's spinach hiding in it, but you can't taste it.

  • janet.peach
    Apr 10, 2012

    Thanks for including your recipe for the Tzatziki Sauce using plain Greek yogurt.  This is great for a guilt-free way to really slather on the sauce! 

  • janet.peach
    Apr 9, 2012

    This now is my favorite meatloaf recipe! It's absolutely delicious! I think I might make my own tzatziki sauce next time using Greek plain low-fat yogurt. As a Pacific NW transplant, I miss all the wonderful Greek food of the Chicago area. I can make this whenever I get a hankering for the flavor!

  • Cat0210
    Mar 25, 2012

    This was quick & easy. I used ground chicken instead of beef/lamb.

  • gypsymal
    Mar 12, 2012

    I had this meatloaf today and it was excellent. However I made my own Tzatziki sauce with 8 ozs Greek yogurt, small cucumber, 2 crushed garlic cloves, pinch salt, 1 1/2 tsp olive oil, 1 tsp red wine vinegar and 1/4 tsp mint and it was all very delicious and will make it again.

  • AndreaCavie
    Feb 3, 2012

    I really enjoyed this meatloaf! I used 1 lb. ground beef and 1 lb. ground lamb. I served it with cucumbers and pita/hummus on the side. I will definitely make it again!

  • keverwann
    Jan 31, 2012

    This was good, but it tasted NOTHING like a Gyro. I served it with onion and lemon rice pilaf and glazed carrots.

  • astasteel
    Jan 31, 2012

    Definitely a keeper.