Buttermilk Meat Loaf

Total Time

Prep: 20 min. Bake: 1 hour + standing


6 servings

Updated: Feb. 08, 2022
Barbecue sauce is a Southwestern staple, so I use it in meat loaf instead of ketchup. The buttermilk and garlic also lend a tangy flavor. Whenever I serve this, it gets rave reviews, even from those who don’t ordinarily care for meat loaf.


  • 1 cup soft bread crumbs
  • 2 large eggs, lightly beaten
  • 1/2 cup finely chopped red onion
  • 6 tablespoons barbecue sauce, divided
  • 1/4 cup buttermilk
  • 2 tablespoons minced fresh parsley
  • 1 teaspoon garlic salt
  • 1/4 teaspoon pepper
  • 1-1/2 pounds ground beef


  1. In a large bowl, combine the bread crumbs, eggs, onion, 4 tablespoons barbecue sauce, buttermilk, parsley, garlic salt and pepper. Crumble beef over mixture and mix well. Shape into a loaf. Place in a greased 11x7-in. baking dish.
  2. Bake, uncovered, at 350° for 50 minutes. Spread with remaining barbecue sauce. Bake 10 minutes longer or until meat is no longer pink and a thermometer reads 160°. Drain; let stand for 10 minutes before slicing.