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Buttermilk Meat Loaf

Barbecue sauce is a Southwestern staple, so I use it in meat loaf instead of ketchup. The buttermilk and garlic also lend a tangy flavor. Whenever I serve this, it gets rave reviews, even from those who don’t ordinarily care for meat loaf.
  • Total Time
    Prep: 20 min. Bake: 1 hour + standing
  • Makes
    6 servings


  • 1 cup soft bread crumbs
  • 2 large eggs, lightly beaten
  • 1/2 cup finely chopped red onion
  • 6 tablespoons barbecue sauce, divided
  • 1/4 cup buttermilk
  • 2 tablespoons minced fresh parsley
  • 1 teaspoon garlic salt
  • 1/4 teaspoon pepper
  • 1-1/2 pounds ground beef


  • In a large bowl, combine the bread crumbs, eggs, onion, 4 tablespoons barbecue sauce, buttermilk, parsley, garlic salt and pepper. Crumble beef over mixture and mix well. Shape into a loaf. Place in a greased 11x7-in. baking dish.
  • Bake, uncovered, at 350° for 50 minutes. Spread with remaining barbecue sauce. Bake 10 minutes longer or until meat is no longer pink and a thermometer reads 160°. Drain; let stand for 10 minutes before slicing.

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Average Rating:
  • LostTime
    Jun 16, 2019

    Easy to make. I will make it again. It was tasty and moist.

  • mimirita
    Jul 24, 2018

    I made a boo boo and added all the BBQ sauce to the in loaf mixture, and I almost never use bread crumbs, I use oats for better nutrition. Only use about 1/2 to 3/4 cup of oats, after all it is a "meat" loaf. Now I always use at least 6 TB BBQ sauce in the loaf. Sometimes I top it with more BBQ, sometimes not. GOOD LOAF.

  • gunslinger
    Mar 13, 2017

    My husband's favorite of all the meatloaf recipes I have tried!Delicious and it held together very well!

  • rfiesty
    Feb 16, 2016


  • Janet Parrish
    Nov 22, 2015

    Most delicious meatloaf I ever ate. I'm watching my salt intake, so had to use a sub. But will always use this recipe.

  • bblatt01
    Nov 10, 2015

    This was surprisingly better than I expected. I used Sweet Baby Ray's BBQ sauce and 1/2 pouch of Onion Soup Mix instead of a chopped up onion. Now one of my favorites! Very good!! And very good the next day, sliced up in a hot sandwich with gravy and mashed potatoes!!

  • danielleylee
    Aug 19, 2015

    I made this recipe tonight. I actually only had a half pound of ground beef 93/7. I made muffin meatloaves with this recipe. I was able to get about 8 muffin sized mini meatloaves. I topped them off with wihpped mashed potatoes pipped using a start-tip. I made them into savory cupcakes and were adorable! The meatloaf recipe has a lot of flavor! I baked the mini loaves at 350 degrees for 25 minutes which might have been too long since the temp was at 190 degrees so maybe try 20 minutes.

  • abashu
    Mar 4, 2015

    Great taste and flavor. I used Montreal steak sauce instead of barbecue sauce.

  • Booplady1035
    Feb 19, 2015

    Totally family loved it . I also cut bacon strips in half and laid over the top of the loaf before putting it in the oven..then the last 10 minutes I spread the BBQ sauce on kinda carmelized the top sauce. So Good

  • wdeckerman
    Dec 1, 2014

    Very moist with good flavor. My family loved this meatloaf and asked me to make it again!