Pepperoni Ziti Casserole Recipe
Pepperoni Ziti Casserole Recipe photo by Taste of Home

Pepperoni Ziti Casserole Recipe

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4.5 13 22
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I took a traditional family recipe and put my own nutritious spin on it to create this casserole. The chopped spinach and turkey pepperoni add color and flair, pleasing both the eyes and the palate. —Andrea Abrahamsen of Brentwood, California
TOTAL TIME: Prep: 20 min. Bake: 30 min.
MAKES:10 servings
TOTAL TIME: Prep: 20 min. Bake: 30 min.
MAKES: 10 servings


  • 1 package (1 pound) uncooked ziti or small tube pasta
  • 1/2 pound lean ground turkey
  • 2 cans (one 29 ounces, one 8 ounces) tomato sauce, divided
  • 1-1/2 cups (6 ounces) shredded part-skim mozzarella cheese, divided
  • 1 can (8 ounces) mushroom stems and pieces, drained
  • 5 ounces frozen chopped spinach, thawed and squeezed dry
  • 1/2 cup reduced-fat ricotta cheese
  • 4 teaspoons Italian seasoning
  • 2 garlic cloves, minced
  • 1/2 teaspoon garlic powder
  • 1/2 teaspoon crushed red pepper flakes
  • 1/4 teaspoon pepper
  • 1/2 cup water
  • 1 tablespoon grated Parmesan cheese
  • 1-1/2 ounces sliced turkey pepperoni

Nutritional Facts

1 cup: 306 calories, 7g fat (3g saturated fat), 37mg cholesterol, 795mg sodium, 42g carbohydrate (0g sugars, 4g fiber), 20g protein Diabetic Exchanges:2-1/2 starch, 2 lean meat 1 vegetabl


  1. Cook pasta according to package directions.
  2. Meanwhile, in a large nonstick skillet, cook turkey over medium heat until no longer pink; drain. Transfer to a large bowl. Add the 29-oz. can tomato sauce, 1 cup mozzarella cheese, mushrooms, spinach, ricotta cheese, Italian seasoning, garlic, garlic powder, pepper flakes and pepper. Drain pasta; fold into turkey mixture.
  3. Transfer to a 13-in. x 9-in. baking dish coated with cooking spray. Combine the water and remaining tomato sauce; pour over pasta mixture. Sprinkle with Parmesan cheese and remaining mozzarella cheese. Top with pepperoni.
  4. Cover and bake at 350° for 25-30 minutes or until bubbly. Uncover; bake 5 minutes longer or until cheese is melted. Yield: 10 servings.
Originally published as Pepperoni Ziti Casserole in Light & Tasty April/May 2003, p39

Medium-Bodied Red Wine

Enjoy this recipe with a medium-bodied red wine such as Chianti, Sangiovese, Malbec or Zinfandel.

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Reviewed Jul. 13, 2015

"No need for the ground turkey. I doubled spinach. I substituted cottage cheese for the ricotta. Delicious!

- Theresa"

Reviewed May. 28, 2015

"The whole family really enjoyed this and I love casseroles, win-win. A lot of flavor in this simple ingredient recipe. Perfect amount of sauce to noodle ratio. Since shredded mozzarella comes in 2 cup bags I used the 2 cups. Thanks for the recipe."

Reviewed Jan. 24, 2015

"Perfect! I must admit when I usually make a baked ziti dish I do not follow a recipe. Not now! This is our new go-to recipe. As a volunteer food editor for Taste of Home I appreciate recipes that are easy to assemble and provide lots of flavor. Not to mention lots of food for a family of five. With or without the pepperoni this is a great dish!"

Reviewed Jun. 21, 2014

"saving recipe! thanky ou for sharing TOH. J."

Reviewed Apr. 16, 2014

"Really please with the way this turned out. Prep took a bit longer than I expected, but overall I was happy with it! Definitely feels healthier than eating a traditional ziti...there is a lot less cheese. If you want more - just add it in!"

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