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Meaty Pasta Casseroles

I love this recipe because it makes two hearty casseroles. Every time I make it I add a little something different, such as extra garlic, to give it an added boost of flavor. —Debra Butcher, Decatur, Indiana
  • Total Time
    Prep: 45 min. Bake: 35 min.
  • Makes
    2 casseroles (6 servings each)


  • 1 package (16 ounces) penne pasta
  • 1 pound ground beef
  • 1 pound bulk Italian pork sausage
  • 1-3/4 cups sliced fresh mushrooms
  • 1 medium onion, chopped
  • 1 medium green pepper, chopped
  • 2 cans (14-1/2 ounces each) Italian diced tomatoes
  • 1 jar (23-1/2 ounces) Italian sausage and garlic spaghetti sauce
  • 1 jar (16 ounces) chunky mild salsa
  • 1 package (8 ounces) sliced pepperoni, chopped
  • 1 cup shredded Swiss cheese, divided
  • 4 cups shredded part-skim mozzarella cheese, divided
  • 1-1/2 cups shredded Parmesan cheese, divided
  • 1 jar (24 ounces) 3-cheese spaghetti sauce


  • Cook pasta according to package directions. Meanwhile, in a Dutch oven, cook beef, sausage, mushrooms, onion and green pepper over medium heat until meat is no longer pink, breaking meat into crumbles; drain.
  • Drain pasta; add to the meat mixture. Stir in the tomatoes, spaghetti sauce, salsa and pepperoni.
  • Preheat oven to 350°. Divide half the pasta mixture between 2 greased 13x9-in. baking dishes. Sprinkle each with 1/4 cup Swiss cheese, 1 cup mozzarella cheese and 1/3 cup Parmesan cheese. Spread 3/4 cup 3-cheese spaghetti sauce over each. Top with remaining pasta mixture and 3-cheese spaghetti sauce. Sprinkle with remaining cheeses.
  • Cover and bake until bubbly, about 25 minutes. Uncover; bake until cheese is melted, about 10 minutes longer.
    Freeze option: Cover unbaked casserole and freeze for up to 3 months. To use, thaw in refrigerator overnight. Remove from refrigerator 30 minutes before baking. Preheat oven to 350°. Bake casserole, covered, 45 minutes. Uncover; bake 10 minutes or until cheese is melted.
Nutrition Facts
1-1/2 cups: 708 calories, 38g fat (16g saturated fat), 106mg cholesterol, 1788mg sodium, 54g carbohydrate (18g sugars, 5g fiber), 38g protein.

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  • tt2b123
    Dec 26, 2019

    No comment left

  • camper77
    Mar 20, 2018

    No comment left

  • Neil
    May 26, 2017

    Made this awhile ago and had the second one in the freezer. Several days ago we lost our Brother-in law to cancer. We pulled the second one out of the freezer and brought it to my Sister's home because we knew there would be a lot of people there. It was a big hit and feed a lot of people. Going to make it again just to have ready in freezer for next emergency.

  • homemaker27
    Jan 17, 2017

    This recipe is fabulous!!! I have a family of 6 so a 9x13 is perfect for us!! And another one to freeze. We were so impressed!!! The only thing I added was a lot of fresh minced garlic (heaping soup spoon full). Added it with the other veggies.

  • SpunkeyKY
    Oct 14, 2015

    This is a keeper. Easy to make and loved by everyone.

  • Juliad0514
    Nov 20, 2014

    This is everyone's absolute favorite thing I make. It's an impressive dish that everyone loves. It's also great because it makes two pans, so you can freeze the second one to eat at a later date.

  • Countryladybug
    Jun 27, 2014

    Loved this dish found it great to make and use at large family functions Simply Delicious 5+ stars from our family.

  • annette.barney
    Aug 18, 2013

    No comment left

  • DrDoom77
    Dec 29, 2012

    No comment left

  • triciak3
    Dec 4, 2012

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