Grilled Cheese and Pepperoni Sandwich

Total Time

Prep/Total Time: 25 min.


4 servings

Updated: Jul. 28, 2023
Who doesn't love a good grilled cheese sandwich recipe? This super decadent version comes fully loaded with pepperoni and five types of cheese!—Josh Rink, Taste of Home Food Stylist
Grilled Cheese and Pepperoni Sandwich Recipe photo by Taste of Home


  • 6 tablespoons butter, softened, divided
  • 8 slices sourdough bread
  • 1/2 cup shredded sharp white cheddar cheese
  • 1/2 cup shredded Monterey Jack cheese
  • 1/2 cup shredded Gruyere cheese
  • 3 tablespoons mayonnaise
  • 3 tablespoons finely shredded Manchego or Parmesan cheese
  • 1/8 teaspoon onion powder
  • 24 slices pepperoni
  • 4 ounces Brie cheese, rind removed and sliced


  1. Spread 3 tablespoons butter on 1 side of bread slices. Place bread, butter side down, in a large cast-iron skillet or electric griddle over medium-low heat until golden brown, 2-3 minutes; remove from heat. In a small bowl, combine cheddar, Monterey Jack and Gruyere. In another bowl, mix together remaining 3 tablespoons butter, mayonnaise, Manchego cheese and onion powder.
  2. To assemble sandwiches, top toasted side of 4 bread slices with pepperoni; add sliced Brie. Sprinkle cheddar cheese mixture evenly over Brie. Top with remaining bread slices, toasted side facing inward. Spread the butter-mayonnaise mixture on the outsides of each sandwich. Place in same skillet; toast until golden brown and cheese is melted, 5-6 minutes on each side. Serve immediately.

Nutrition Facts

1 sandwich: 719 calories, 55g fat (29g saturated fat), 134mg cholesterol, 1207mg sodium, 30g carbohydrate (3g sugars, 1g fiber), 27g protein.