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Artichoke & Spinach Chicken Casserole

Total Time

Prep: 30 min. Bake: 45 min.


8 servings

Updated: Jan. 04, 2023
Try this homey and comforting casserole for an alternate main dish at Thanksgiving. The spinach adds nice color, and the red pepper flakes add a pleasant, mild heat. —Janice Christofferson, Eagle River, Wisconsin
Artichoke & Spinach Chicken Casserole Recipe photo by Taste of Home


  • 3 cups uncooked bow tie pasta
  • 2 tablespoons butter
  • 1/2 pound sliced fresh mushrooms
  • 1 medium onion, chopped
  • 2 large eggs
  • 1-1/2 cups 2% milk
  • 1 teaspoon Italian seasoning
  • 1/2 teaspoon salt
  • 1/4 teaspoon pepper
  • 1/4 to 1/2 teaspoon crushed red pepper flakes
  • 3 cups cubed cooked chicken
  • 1 can (14 ounces) water-packed quartered artichoke hearts, rinsed and drained
  • 1 package (10 ounces) frozen chopped spinach, thawed and squeezed dry
  • 2 cups shredded Monterey Jack cheese
  • 2 tablespoons grated Parmesan cheese
  • 1/3 cup seasoned bread crumbs
  • 2 tablespoons grated Parmesan cheese
  • 1 tablespoon butter, melted
  • 1/2 teaspoon paprika


  1. Preheat oven to 350°. Cook the pasta according to package directions; drain.
  2. In a large skillet, heat the butter over medium-high heat; sauté the mushrooms and onion until tender. Remove from heat.
  3. In a large bowl, whisk together eggs, milk and seasonings. Stir in chicken, artichoke hearts, spinach, cheeses and mushroom mixture. Stir in pasta.
  4. Transfer to a greased 13x9-in. baking dish. Bake, covered, 40 minutes.
  5. Mix the topping ingredients; sprinkle over casserole. Bake, uncovered, until bubbly and topping is golden brown, 5-10 minutes.

Nutrition Facts

1-1/2 cups: 455 calories, 21g fat (11g saturated fat), 136mg cholesterol, 713mg sodium, 34g carbohydrate (5g sugars, 3g fiber), 34g protein.

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