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Mexican Chicken Alfredo

One family member likes Italian; another likes Mexican. They’ll never compromise when this is on the menu. —Tia Woodley, Stockbridge, Georgia
  • Total Time
    Prep: 25 min. Bake: 30 min.
  • Makes
    2 casseroles (4 servings each)


  • 1 package (16 ounces) gemelli or spiral pasta
  • 2 pounds boneless skinless chicken breasts, cubed
  • 1 medium onion, chopped
  • 1/4 teaspoon salt
  • 1/4 teaspoon pepper
  • 1 tablespoon canola oil
  • 2 jars (15 ounces each) Alfredo sauce
  • 1 cup grated Parmesan cheese
  • 1 cup medium salsa
  • 1/4 cup 2% milk
  • 2 teaspoons taco seasoning


  • Preheat oven to 350°. Cook pasta according to package directions.
  • Meanwhile, in a large skillet over medium heat, cook chicken, onion, salt and pepper in oil until chicken is no longer pink. Stir in Alfredo sauce; bring to a boil. Stir in cheese, salsa, milk and taco seasoning.
  • Drain pasta; toss with chicken mixture. Divide between 2 greased 8-in. square baking dishes. Cover and bake until bubbly, 30-35 minutes.
    Freeze option: Cover and freeze unbaked casserole up to 3 months. To use, thaw in refrigerator overnight. Remove from refrigerator 30 minutes before baking. Preheat oven to 350°. Bake casserole, covered, until bubbly, 50-60 minutes.
Nutrition Facts
1-1/2 cups: 559 calories, 20g fat (11g saturated fat), 102mg cholesterol, 899mg sodium, 55g carbohydrate (4g sugars, 3g fiber), 40g protein.

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Average Rating:
  • Gramma Amy
    Sep 12, 2019

    Fast and Easy.... enjoyed this casserole. Gave 4 stars because we thought it needs a little more flavor... so I now add green peppers with the onion and some garlic powder. It was very good, and we will use it again!

  • gunslinger
    Aug 20, 2019

    Very tasty! Next time I would increase the taco seasoning for more spice. A really nice twist on regular chicken alfredo!

  • Nancilb
    Mar 21, 2019

    Love this

  • pcinant
    Oct 21, 2018

    Loved it. Made half of recipe and used 1/2 pkg of taco seasoning as suggested by others.will make again.

  • brodie123
    Jul 5, 2018

    I added diced green chilies and grilled fresh corn cob corn. It was excellent

  • PrplMonky5
    May 4, 2018

    I cut this recipe in half, then of that only made half of it for my husband and I and froze the other half (so a 1/4 each of the original recipe). This was really easy to make and it was VERY yummy. I used taco seasoning with 25% less sodium, and increased the amount from 1 tsp to 1.5 tsp. I also added in some chopped sweet red pepper. We really liked this recipe, I will definitely make this again.

  • Summersh
    Jun 21, 2017

    We loved it. Super easy to make.

  • dschultz01
    Feb 11, 2017

    Great twist on chicken Alfredo. Even my wife, who does not care for Alfredo dishes, liked this one. Pretty easy to make also.

  • hchambers
    Nov 19, 2016

    The kids loved it. I used the entire packet of taco seasoning and ground turkey because that was what I had on hand. I will definitely make this again.

  • HaleysFunFixins
    Mar 22, 2016

    Delicious... I made it once as is with chicken and it was great, but the second time around I substituted turkey kielbasa for the chicken and it made the dish even better! The key is using a salsa that you really like.