Combine seasonings; rub over entire roast. Cover and refrigerate at least 2 hours.
Preheat oven to 425°. Place roast on a rack in a large shallow roasting pan. Bake, uncovered, 40-60 minutes or until meat reaches desired doneness (for medium-rare, a thermometer should read 135°; medium, 140°; medium-well, 145°). Let stand 10-15 minutes before slicing.