Preheat oven to 400°. In a large skillet, cook beef and onion over medium heat until meat is no longer pink; drain. Stir in the tomato sauce, ketchup and pepper. Spoon half into a greased 8-in. square baking dish; sprinkle with half of the cheese. Repeat layers.
Place biscuits around edges of dish. Bake, uncovered, until the meat mixture is bubbly and biscuits are golden brown, 18-22 minutes.