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Mexican Chicken Alfredo Recipe
Mexican Chicken Alfredo Recipe photo by Taste of Home

Mexican Chicken Alfredo Recipe

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One family member likes Italian; another likes Mexican. They’ll never compromise when this is on the menu. —Tia Woodley, Stockbridge, Georgia
TOTAL TIME: Prep: 25 min. Bake: 30 min.
MAKES:8 servings
TOTAL TIME: Prep: 25 min. Bake: 30 min.
MAKES: 8 servings


  • 1 package (16 ounces) gemelli or spiral pasta
  • 2 pounds boneless skinless chicken breasts, cubed
  • 1 medium onion, chopped
  • 1/4 teaspoon salt
  • 1/4 teaspoon pepper
  • 1 tablespoon canola oil
  • 2 jars (15 ounces each) Alfredo sauce
  • 1 cup grated Parmesan cheese
  • 1 cup medium salsa
  • 1/4 cup 2% milk
  • 2 teaspoons taco seasoning

Nutritional Facts

1-1/2 cups equals 559 calories, 20 g fat (11 g saturated fat), 102 mg cholesterol, 899 mg sodium, 55 g carbohydrate, 3 g fiber, 40 g protein.


  1. Preheat oven to 350°. Cook pasta according to package directions.
  2. Meanwhile, in a large skillet over medium heat, cook chicken, onion, salt and pepper in oil until chicken is no longer pink. Stir in Alfredo sauce; bring to a boil. Stir in cheese, salsa, milk and taco seasoning.
  3. Drain pasta; toss with chicken mixture. Divide between two greased 8-in.-square baking dishes. Cover and bake 30-35 minutes or until bubbly.
    Freeze option: Cover and freeze unbaked casserole up to 3 months. To use, thaw in refrigerator overnight. Remove from refrigerator 30 minutes before baking. Preheat oven to 350°. Cover and bake 50-60 minutes or until bubbly.
    Yield: 2 casseroles (4 servings each).
Originally published as Mexican Chicken Alfredo in Simple & Delicious August/September 2011, p22

Nutritional Facts

1-1/2 cups equals 559 calories, 20 g fat (11 g saturated fat), 102 mg cholesterol, 899 mg sodium, 55 g carbohydrate, 3 g fiber, 40 g protein.

Full-Bodied White Wine

Enjoy this recipe with a full-bodied white wine such as Chardonnay or Viognier.

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Reviewed Apr. 20, 2015

"Great recipe! I was out of salsa so I used green enchilada sauce instead and I used a whole packet of taco seasoning. Whole family loved it!!"

Reviewed Dec. 22, 2014

"When I first came across this recipe, I thought that the fusion of chicken Alfredo and Mexican was a bit strange, but it looked so good! I loved how it was creamy, but still had some kick to it. I added green chilies and loved them in there. Now my apartment smells like my dinner!"

Reviewed Sep. 25, 2014

"We really liked this dish! I have a friend who thinks everything is hot including salsa so we put sour cream on top and she even thought it was delicious! I was out of milk so I used buttermilk."

Reviewed Sep. 17, 2014

"This recipe is a new favorite in our house. I agree with other reviewers and will increase the amount of taco seasoning next time but it was still delicious."

Reviewed Sep. 3, 2014

"I made this dish for my family and everyone loved it! Now, it is a favorite of my sisters and she makes it for her friends and family. I made it exactly as stated. Makes yummy leftovers for lunch the next day!"

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