Meaty Pasta Casseroles Recipe
Meaty Pasta Casseroles Recipe photo by Taste of Home
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Meaty Pasta Casseroles Recipe

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I love this recipe because it makes a lot—two hearty casseroles. Every time I fix it, I add something different, such as extra garlic, to give it a little extra flavor. —Debra Butcher, Decatur, Indiana
TOTAL TIME: Prep: 45 min. Bake: 35 min.
MAKES:12 servings
TOTAL TIME: Prep: 45 min. Bake: 35 min.
MAKES: 12 servings


  • 1 package (16 ounces) penne pasta
  • 1 pound ground beef
  • 1 pound bulk Italian pork sausage
  • 1-3/4 cups sliced fresh mushrooms
  • 1 medium onion, chopped
  • 1 medium green pepper, chopped
  • 2 cans (14-1/2 ounces each) Italian diced tomatoes
  • 1 jar (23-1/2 ounces) Italian sausage and garlic spaghetti sauce
  • 1 jar (16 ounces) chunky mild salsa
  • 1 package (8 ounces) sliced pepperoni, chopped
  • 1 cup (4 ounces) shredded Swiss cheese, divided
  • 4 cups (16 ounces) shredded part-skim mozzarella cheese, divided
  • 1-1/2 cups shredded Parmesan cheese, divided
  • 1 jar (24 ounces) three-cheese spaghetti sauce

Nutritional Facts

1 each: 669 calories, 34g fat (15g saturated fat), 90mg cholesterol, 1825mg sodium, 54g carbohydrate (20g sugars, 5g fiber), 37g protein .


  1. Cook pasta according to package directions. Meanwhile, in a Dutch oven, cook beef, sausage, mushrooms, onion and green pepper over medium heat until meat is no longer pink; drain.
  2. Drain pasta; add to the meat mixture. Stir in the tomatoes, sausage and garlic spaghetti sauce, salsa and pepperoni.
  3. Preheat oven to 350° . Divide half of pasta mixture between two greased 13x9-in. baking dishes. Sprinkle each with 1/4 cup Swiss cheese, 1 cup mozzarella cheese and 1/3 cup Parmesan cheese. Spread 3/4 cup of three-cheese spaghetti sauce over each. Top with remaining pasta mixture and three-cheese spaghetti sauce. Sprinkle with remaining cheeses.
  4. Cover and bake 25 minutes. Uncover; bake 10 minutes or until cheese is melted.
    Freeze option: Cover unbaked casserole and freeze for up to 3 months. To use, thaw in refrigerator overnight. Remove from refrigerator 30 minutes before baking. Preheat oven to 350°. Bake casserole, covered, 45 minutes. Uncover; bake 10 minutes or until cheese is melted.
    Yield: 2 casseroles (6 servings each).
Originally published as Meaty Pasta Casseroles in Taste of Home August/September 2008, p39

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SpunkeyKY 234932
Reviewed Oct. 14, 2015

"This is a keeper. Easy to make and loved by everyone."

Juliad0514 105698
Reviewed Nov. 20, 2014

"This is everyone's absolute favorite thing I make. It's an impressive dish that everyone loves. It's also great because it makes two pans, so you can freeze the second one to eat at a later date."

Countryladybug 107418
Reviewed Jun. 27, 2014

"Loved this dish found it great to make and use at large family functions Simply Delicious 5+ stars from our family."

Jeannines1949 115076
Reviewed Nov. 13, 2012

"This recipe is fabulous!! There are only two of us, so I put in 8x8 casseroles, cooked one and froze the remainder. We have leftovers for tomorrow! Cant wait to finish. It does make a lot. It did take me a little longer than 45 minutes to prepare, but was worth the time!!! Thank you so much and keep those recipes coming!!!"

123nancy 158194
Reviewed Oct. 18, 2012

"I have made this dish twice now for guest. It is a keeper and I look forward to making it again."

swinny 210056
Reviewed Sep. 30, 2012

"Delicious! I made this with italian turkey sausage..."

icensnow80 115074
Reviewed Sep. 13, 2012

"Amazing dish! I didn't need to change a thing - this has SO much flavor and was so easy to make! A BIG HIT with my family, I will definitely be making it again! Thanks!!"

cherikzaiger 160437
Reviewed Sep. 9, 2012

"Thoroughly enjoyed this recipe! Just use your imagination for lighter substitutes if you want less fat/sodium, etc. However, I LOVE getting recipes just like this. I rarely follow the recipe word for word, but add and delete what I want and it is superb!!"

tsuop 173452
Reviewed Sep. 8, 2012

"I agree there are a lot of ways to "lighten" this up, chicken sausage for example. Recipes are created as a guide, use your imagination. I don't like pepperoni, so I eliminated that. I doubt the "recipe police" will be after me."

Lizzie1013 173451
Reviewed Sep. 8, 2012

"Regi M, thank you for your excellent comments. Wonderful recipe! Thanks to Debra."

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