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Creamy Pepperoni Ziti Recipe

Creamy Pepperoni Ziti Recipe

You can easily feed a crowd with this simple dish that's ready in about 40 minutes. Its comforting sauce will become a fast favorite at your next potluck or weeknight dinner. —Charlane Gathy, Lexington, Kentucky
TOTAL TIME: Prep: 15 min. Bake: 25 min. YIELD:9 servings


  • 1 package (16 ounces) ziti or small tube pasta
  • 1 can (10-3/4 ounces) condensed cream of mushroom soup, undiluted
  • 3/4 cup shredded part-skim mozzarella cheese
  • 3/4 cup chopped pepperoni
  • 1/2 cup each chopped onion, mushrooms, green pepper and tomato
  • 1/2 cup half-and-half cream
  • 1/4 cup chicken broth
  • 1/4 teaspoon salt
  • 1/4 teaspoon garlic powder
  • 1/4 teaspoon pepper
  • 1/2 cup grated Parmesan cheese


  • 1. Cook pasta according to package directions; drain. In a large bowl, combine the pasta, soup, mozzarella cheese, pepperoni, onion, mushrooms, green pepper, tomato, cream, broth and seasonings.
  • 2. Transfer to a greased 13-in. x 9-in. baking dish. Sprinkle with Parmesan cheese. Cover and bake at 350° for 20 minutes. Uncover; bake 5-10 minutes longer or until bubbly. Yield: 9 servings.

Nutritional Facts

1 cup: 340 calories, 12g fat (6g saturated fat), 27mg cholesterol, 696mg sodium, 43g carbohydrate (4g sugars, 2g fiber), 15g protein. Diabetic Exchanges: 3 starch, 1 high-fat meat, 1/2 fat.

Reviews for Creamy Pepperoni Ziti

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ChocolateMudCake User ID: 162783 153730
Reviewed Oct. 13, 2013

"This tastes delicious! My family requests it often. Thank You for sharing!"

msu4two User ID: 3762709 169792
Reviewed Sep. 22, 2013

"I made this tonight, and really liked it! I sauteed the vegetables prior to mixing them with the pasta mixture, and added 1/2 cup of chicken broth instead of 1/4 cup, as it seemed a bit dry. Although I like pepperoni, there was a bit too much for my taste, so I'll probably only use about 1/3 cup next time. I'll definitely make this again."

jmketchum1 User ID: 921033 153729
Reviewed Aug. 12, 2013

"Everyone loved it! Will make again"

blessedhomemaker User ID: 1012239 72509
Reviewed Aug. 29, 2012

"Fantastic! I agree with Jennifer that it tasted just like pizza toppings.I used penne pasta,cream instead of 1/2 and 1/2(the measurement called for plus a couple extra splashes),only half cut the pepperoni slices, and added 3/4C. more mozzarella cheese.We will have this again!"

deannasnz User ID: 6542477 80476
Reviewed May. 30, 2012

"I thought it was boring. Adding chicken and vegetables to the leftovers improved it."

MelodyMahala User ID: 4582527 99518
Reviewed Sep. 27, 2011

"I used the mini ziti pasta shells, the mini pepperoni slices and half a jar of sliced mushrooms instead of fresh. I also used fat free half-and-half and added another cup of shredded mozzarella on top of the casserole mixed with the parmesan cheese. It was perfect!"

Peaches_77 User ID: 4311371 80462
Reviewed Aug. 29, 2011

"Really good, but I plan to change a couple of things the next time - it just says "chopped pepperoni" - I chopped it too small - think it would be better with bigger chunks. Also swap out the green peppers with roasted red peppers & will maybe add some chicken for a little extra substance."

brittanyminikus User ID: 5545360 209181
Reviewed Feb. 28, 2011

"Amazing! My husband couldn't stop complimenting the dish. I did add more cream of mushroom soup, more pepperoni, and sauted the veggies."

LaFrenierM User ID: 5629873 209180
Reviewed Feb. 19, 2011

"Saute the mushrooms, green peppers, onions, & add another can of cream of mushroom soup!!! :) A keeper! We enjoyed it much better the second time around when I made these changes!"

Flenner User ID: 2160342 80461
Reviewed Feb. 18, 2011

"This was sooo good. I added extra soup and a handful more pepperoni and cheese"

jshreckengast User ID: 3220777 156169
Reviewed Jan. 18, 2011

"So good. Will definitely keep this in the regular rotation."

ape360 User ID: 5738783 169652
Reviewed Jan. 4, 2011

"sometimes less is more... i leave out the mushrooms,green pepper, and onion and it still tastes great! . LOVE IT"

JenniferMarie412 User ID: 4878762 153727
Reviewed Jun. 19, 2010

"This pasta was GREAT! My boyfriend loved it too... it tastes like a supreme pizza... SO good and definitely a keeper! Also nice for days you forget to thaw out meat (which is why I made it!)"

ZTRAK User ID: 1104282 167388
Reviewed Jan. 16, 2010

"We love this flavorful recipe and I make it often. I prefer using less pasta (1/2 pkg.) which makes the finished casserole more moist."

sarahsomerlot User ID: 3916644 156168
Reviewed Mar. 5, 2009

"I thought this recipe was wonderful. With a tossed salad and some garlic bread, my family loved it!"

cntbailey User ID: 1507453 98040
Reviewed Feb. 4, 2009

"This was good but next time I make it I will add another can of cream of Mushroom soup. I little dry but will make this again."

scrambledwithcheese User ID: 1233902 98039
Reviewed Dec. 15, 2008

"Awful, just awful. Hated it."

hhe User ID: 1548239 169649
Reviewed Nov. 16, 2008

"Loved this recipe, my husband really enjoyed it aswell. It was simple, tasty, and really hearty. Definatly emailing it to all my friends"

bowler_jen User ID: 1977143 153725
Reviewed Oct. 31, 2008

"didn't like the un-sauteed onions, but the flavor in this is amazing and very quick to prepare. Will make again!"

aKelsey User ID: 3254685 156167
Reviewed Oct. 1, 2008

"Easier to prepare than falling off a log and just as affordable...which is good, because my husband couldn't stop eating it!"

eveann78 User ID: 3260585 72508
Reviewed Sep. 26, 2008

"Wow this dish was amazing! Very easy to prepare. I actually used turkey pepperoni and frozen chopped stir fry mix so I didnt even have to cut up any peppers or onions. I didnt have mushrooms but it was fabulous without them. Im so glad there are leftovers!!"

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Wine Pairings

Full-Bodied White Wine

Enjoy this recipe with a full-bodied white wine such as Chardonnay or Viognier.