Creamy Pepperoni Ziti Recipe
Creamy Pepperoni Ziti Recipe photo by Taste of Home
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Creamy Pepperoni Ziti Recipe

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You can easily feed a crowd with this simple dish that's ready in about 40 minutes. Its comforting sauce will become a fast favorite at your next potluck or weeknight dinner. —Charlane Gathy, Lexington, Kentucky
TOTAL TIME: Prep: 15 min. Bake: 25 min.
MAKES:9 servings
TOTAL TIME: Prep: 15 min. Bake: 25 min.
MAKES: 9 servings


  • 1 package (16 ounces) ziti or small tube pasta
  • 1 can (10-3/4 ounces) condensed cream of mushroom soup, undiluted
  • 3/4 cup shredded part-skim mozzarella cheese
  • 3/4 cup chopped pepperoni
  • 1/2 cup each chopped onion, mushrooms, green pepper and tomato
  • 1/2 cup half-and-half cream
  • 1/4 cup chicken broth
  • 1/4 teaspoon salt
  • 1/4 teaspoon garlic powder
  • 1/4 teaspoon pepper
  • 1/2 cup grated Parmesan cheese

Nutritional Facts

1 cup: 340 calories, 12g fat (6g saturated fat), 27mg cholesterol, 696mg sodium, 43g carbohydrate (4g sugars, 2g fiber), 15g protein. Diabetic Exchanges: 3 starch, 1 high-fat meat, 1/2 fat.


  1. Cook pasta according to package directions; drain. In a large bowl, combine the pasta, soup, mozzarella cheese, pepperoni, onion, mushrooms, green pepper, tomato, cream, broth and seasonings.
  2. Transfer to a greased 13-in. x 9-in. baking dish. Sprinkle with Parmesan cheese. Cover and bake at 350° for 20 minutes. Uncover; bake 5-10 minutes longer or until bubbly. Yield: 9 servings.
Originally published as Creamy Pepperoni Ziti in Taste of Home

Full-Bodied White Wine

Enjoy this recipe with a full-bodied white wine such as Chardonnay or Viognier.

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ChocolateMudCake User ID: 162783 153730
Reviewed Oct. 13, 2013

"This tastes delicious! My family requests it often. Thank You for sharing!"

msu4two User ID: 3762709 169792
Reviewed Sep. 22, 2013

"I made this tonight, and really liked it! I sauteed the vegetables prior to mixing them with the pasta mixture, and added 1/2 cup of chicken broth instead of 1/4 cup, as it seemed a bit dry. Although I like pepperoni, there was a bit too much for my taste, so I'll probably only use about 1/3 cup next time. I'll definitely make this again."

jmketchum1 User ID: 921033 153729
Reviewed Aug. 12, 2013

"Everyone loved it! Will make again"

blessedhomemaker User ID: 1012239 72509
Reviewed Aug. 29, 2012

"Fantastic! I agree with Jennifer that it tasted just like pizza toppings.I used penne pasta,cream instead of 1/2 and 1/2(the measurement called for plus a couple extra splashes),only half cut the pepperoni slices, and added 3/4C. more mozzarella cheese.We will have this again!"

deannasnz User ID: 6542477 80476
Reviewed May. 30, 2012

"I thought it was boring. Adding chicken and vegetables to the leftovers improved it."

MelodyMahala User ID: 4582527 99518
Reviewed Sep. 27, 2011

"I used the mini ziti pasta shells, the mini pepperoni slices and half a jar of sliced mushrooms instead of fresh. I also used fat free half-and-half and added another cup of shredded mozzarella on top of the casserole mixed with the parmesan cheese. It was perfect!"

Peaches_77 User ID: 4311371 80462
Reviewed Aug. 29, 2011

"Really good, but I plan to change a couple of things the next time - it just says "chopped pepperoni" - I chopped it too small - think it would be better with bigger chunks. Also swap out the green peppers with roasted red peppers & will maybe add some chicken for a little extra substance."

brittanyminikus User ID: 5545360 209181
Reviewed Feb. 28, 2011

"Amazing! My husband couldn't stop complimenting the dish. I did add more cream of mushroom soup, more pepperoni, and sauted the veggies."

LaFrenierM User ID: 5629873 209180
Reviewed Feb. 19, 2011

"Saute the mushrooms, green peppers, onions, & add another can of cream of mushroom soup!!! :) A keeper! We enjoyed it much better the second time around when I made these changes!"

Flenner User ID: 2160342 80461
Reviewed Feb. 18, 2011

"This was sooo good. I added extra soup and a handful more pepperoni and cheese"

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