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Chicken Penne Casserole Recipe
Chicken Penne Casserole Recipe photo by Taste of Home

Chicken Penne Casserole Recipe

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4.5 84
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This is my family’s favorite casserole recipe. I make it every week or two and we never tire of it. I like that I can clean my kitchen and then relax while it bakes. It won’t disappoint! —Carmen Vanosch, Vernon, British Columbia
TOTAL TIME: Prep: 35 min. Bake: 45 min.
MAKES:4 servings
TOTAL TIME: Prep: 35 min. Bake: 45 min.
MAKES: 4 servings


  • 1 pound boneless skinless chicken thighs, cut into 1-inch pieces
  • 1/2 cup each chopped onion, green pepper and sweet red pepper
  • 1 teaspoon each dried basil, oregano and parsley flakes
  • 1/2 teaspoon salt
  • 1/2 teaspoon crushed red pepper flakes
  • 1 tablespoon canola oil
  • 3 garlic cloves, minced
  • 1-1/2 cups uncooked penne pasta
  • 1 can (14-1/2 ounces) diced tomatoes, undrained
  • 3 tablespoons tomato paste
  • 3/4 cup chicken broth
  • 2 cups (8 ounces) shredded part-skim mozzarella cheese
  • 1/2 cup grated Romano cheese


  1. In a large saucepan, saute the chicken, onion, peppers and seasonings in oil until chicken is no longer pink. Add garlic; cook 1 minute longer.
  2. Cook pasta according to package directions. Meanwhile, process tomatoes and tomato paste in a blender; add to chicken mixture. Stir in broth. Bring to a boil. Reduce heat; cover and simmer for 10-15 minutes or until slightly thickened.
  3. Drain pasta; toss with chicken mixture. Spoon half of the mixture into a greased 2-qt. baking dish. Sprinkle with half of the cheeses. Repeat layers.
  4. Cover and bake at 350° for 30 minutes. Uncover; bake 15-20 minutes longer or until heated through. Yield: 4 servings.
Originally published as Chicken Penne Casserole in Simple & Delicious January/February 2008, p35

Medium-Bodied Red Wine

Enjoy this recipe with a medium-bodied red wine such as Chianti, Sangiovese, Malbec or Zinfandel.

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Reviewed Sep. 17, 2015

"Really enjoyed this recipe!!!! Loved the little bit of heat the crushed red pepper flakes gave it! This is Definitely a keeper!"

Reviewed Jul. 18, 2015

"Still needs more flavor. This will probably be better tomorrow. It takes a very long time to make though, so I'm not sure if I'll make this again. I think it's a great base recipe for sure. I wanted to rate this as is and not make any changes."

Reviewed May. 7, 2015

"Delicious! We all loved it and will make it again~"

Reviewed May. 3, 2015

"Very flavorful! Does take awhile to prepare, but its worth it!"

Reviewed Mar. 31, 2015

"Made this tonight, full well thinking it would be better tomorrow after the flavors blended. I'm sure it will be, but it was pretty darn fantastic right away! I didn't have Romano cheese, but used fresh-grated Parmesan. Very acceptable substitution!"

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